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EX-527 was used at 1-10 µM in vitro and in cellular assays
Biomed Pharmacother
9(3):184-91
In vivo Tasquinimod was effective as a monotherapeutic agent against human prostate
FG-4592 (Roxadustat) - HIF Prolyl-Hydroxylases Inhibitor. CAS# 808118-40-3 Catalog No.:M60263-10S EX-527 was used at 1-10FG 4592 (Roxadustat), CAS No. 808118 40 3, is a potent, selective and bioavailable inhibitor of hypoxia inducible factor prolyl hydroxylase. It is an analog of 2 oxoglutarate (2 OG) to inhibit HIF PH and prevent HIF turnover. While little has been published regarding the actions of this compound, similar HIF PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.
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